Anis A’lliya Abdul Latifa, Kai Wei Leeb, Kelly Phangc, Aneesa Abdul Rashidd, Nee Nee Chane, Suat Cheng Pehf, Thiruventhiran Thilaganathang, Pei Boon Ooia,h*
aDepartment of Medical Sciences, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia, bDepartment of Pre‑Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Malaysia, cFaculty of Psychology and Social Sciences, University of Cyberjaya, Selangor, Malaysia, dDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, eDepartment of Education, Faculty of Social Sciences and Liberal Arts, UCSI University, Kuala, Lumpur, Malaysia, fJeffrey Sachs Center, School of Interdisciplinary Studies, Sunway University, Selangor, Malaysia, gDepartment of Nephrology, Sunway Medical Centre, Selangor, Malaysia, hDepartment of General Studies, School of Interdisciplinary Studies, Sunway University, Selangor, Malaysia
Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation
Abstract
Objectives: This systematic review aims to identify influencing factors of medication adherence behavior in patients with end‑stage renal disease (ESRD), with a special interest in patient‑related factors based on the World Health Organization adherence model. Materials and Methods: Primary electronic databases comprising PubMed, Scopus, Web of Science, Embase and Cochrane Library, as well as ProQuest (Health and Medical), ProQuest (Psychology), and EBSCOHost (APA PsychARTICLES) were used to search for literature on patient‑related factors in medication adherence, from inception till August 31, 2021. Results: 479 articles were identified and six articles meeting eligibility criteria were reviewed and remained in this systematic review. The present review found that despite different tools being used to measure ESRD’s perception of medication’s necessity and beliefs, there was a profound association between perception and beliefs with medication adherence behavior. There is a positive relationship between knowledge, belief, educational level, ethnicity, female, and medication adherence behavior. Mixed finding was reported between perception, age, and medication adherence behavior. However, there were no studies on patients’ attitudes and medication adherence behavior as suggested in the WHO adherence model. Conclusion: Only a limited number of patient‑related factors were available for evaluation in the current systematic review. Additional research is needed to advance the understanding of medication adherence behavior affected by patient‑related factors on the medication and illness. However, the findings must be taken with caution because of the limited studies included in this review.
Keywords: Beliefs, End‑stage renal disease, Knowledge attitude, Medication adherence, WHO adherence model
