Yu-Huai Hoa, Han-Chuan Chuangb, Chorng-Jang Layc, d, Chun-Lung Wangc, d, Yeong-Shu Tsaia, Lih-Shinn Wanga, d, Chen-Chi Tsaic, d
a Division of Infectious Diseases, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
b Division of Infectious Diseases, Department of Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, New Taipei City, Taiwan
c Division of Infectious Diseases, Department of Medicine, Buddhist Tzu Chi General Hospital, Dalin Branch, Chiayi, Taiwan
d School of Medicine, Tzu Chi University, Hualien, Taiwan
Abstract
Objective
To better understand Aeromonas-involved polymicrobial bacteremia (AIPMB).
Materials and Methods
We conducted a retrospective analysis of patients with AIPMB admitted to three large referral hospitals in Taiwan between 2001 and 2008.
Results
Of a total of 62 patients with AIPMB, 22 had healthcare-associated infection and 40 had community-acquired infection. Enterobacteriaceae was the most common concurrent pathogen (82%). The leading underlying diseases/conditions in the affected patients were solid cancers (45%), recent gastric acid suppressant therapy (39%) and liver cirrhosis (26%). More than 95% of the Aeromonas isolates were susceptible to an aminoglycoside, a third- or fourth-generation cephalosporin, imipenem or ciprofloxacin. Antibiotic susceptibilities did not significantly differ between Aeromonas isolates in patients with healthcare-associated AIPMBs and those in patients with community-acquired AIPMBs. Coinfection with Enterobacteriaceae occurred more commonly in community-acquired AIPMB (93% vs. 64%; p = 0.012).
Conclusions
AIPMB occurred commonly in patients with liver cirrhosis, solid cancers or recent gastric acid suppressant therapy. Enterobacteriaceae were the most common concurrent pathogens. Similar antibiotic profiles were found in Aeromonas isolates of healthcare-associated and community-acquired AIPMBs.
Keywords
Aeromonas; Bacteremia; Polymicrobial
