Granular cell tumor of the left maxillary paranasal sinus in a 24-year-old man

Chia-Fen Yang^a, Szu-Ying Chin^{b, c}

a Department of Pathology, En Chu Kong Hospital, New Taipei City, Taiwan
b Department of Pathology, Buddhist Tzu Chi General Hospital, Taipei Branch, New Taipei City, Taiwan
c Department of Pathology, Buddhist Tzu Chi General Hospital, Dalin Branch, Chiayi, Taiwan

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Abstract
Granular cell tumors (GCTs) are uncommon benign lesions which usually occur in the head and neck region. However, paranasal sinus presentation is extremely rare. We report a case of a 24-year-old man with clinical symptoms of chronic sinusitis, which is believed to be the first reported case arising from the paranasal sinuses in the English literature. His symptoms included bilateral nasal obstruction, discharge, postnasal drip, and hyposmia. He received a multiple sinusectomy and there was no evidence of recurrence in the 6-month follow-up. We also summarize the clinical information, clinical presentation, microscopic picture, treatment, and patient status after treatment of three previously reported cases involving naso-paranasal areas along with our case. The diagnostic criteria for malignant transformation and the role of bone invasion are also reviewed.

Keywords
Bone invasion; Granular cell tumor; Maxilla; Nasal cavity; Paranasal sinus