Iatrogenic invasive otomycosis

Chao-Lan Hsu^a, Cheng-Wei Chen^a, Hua-Kung Wang^b

^a Department of Otolaryngology, En Chu Kong Hospital, New Taipei City, Taiwan
^b Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, Taiwan

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Abstract
Otomycosis usually develops in hot humid climates, and patients with otomycosis generally show a good response to medical treatment. However, invasive otomycosis is rarely observed in immunocompetent patients. The predisposing factors for invasive otomycosis include malignant neoplasms and increased use of steroids and broad-spectrum antibiotics. We report a unique case of iatrogenic invasive otomycosis in a 35-year-old woman who had been given ofloxacin eardrops over a long period, which led to an invasive fungal infection. The patient showed no response to general antifungal agents, but the infection was successfully controlled with voriconazole.

Keywords
Aspergillus niger; Otomycosis; Ototopical drops; Voriconazole