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Hyalinizing trabecular tumor, a rare histologically unique tumor of the thyroid, coexisting with papillary thyroid carcinoma

Chiu‑Hsuan Cheng*
Department of Anatomical Pathology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation


A 60‑year‑old woman with a history of well‑controlled hypertension, type II diabetes mellitus, and hyperlipidemia presented to our hospital due to neck enlargement for 5 months. Her neck ultrasonography disclosed three well‑defined tumors, a 3.43 cm × 2.03 cm hypoechoic nodule at the right lower thyroid, a 0.68 cm × 0.8 cm heterogeneous nodule with calcification at the right upper thyroid, and a 0.51 cm × 0.36 cm hypoechoic nodule at the left thyroid. Fine‑needle aspiration (FNA) cytology smears from the first and second nodules were reported as the Bethesda s stem for reporting thyroid cytology category‑II (TBS‑II). The patient was in the euthyroid state. The serum antithyroglobulin antibody level was high (53.1 IU/mL). Intraoperative frozen section of the left nodule proved to be
papillary thyroid carcinoma (PTC). Bilateral total thyroidectomy was performed. The patient recovered well without any complication and was arranged regular follow‑ups.






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