Tzyy‑Ling Chuanga,b, Mei‑Hua Chuangc,d, Chun‑Hung Line, Shih‑Chin Choua, Yuh‑Feng Wanga,b,f*
aDepartment of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan, bSchool of Medicine, Tzu Chi University, Hualien, Taiwan, cFaculty of Pharmacy, National Yang‑Ming University, Taipei, Taiwan, dDepartment of Pharmacology, School of Medicine, Tzu Chi University, Hualien, Taiwan, eDepartment of General Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan, fCenter of Preventive Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan
Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation
Objective: To examine the biofactors associated with bone mineral density (BMD) in southern Taiwanese adults. Materials and Methods: The medical records of 3242 adults who underwent health examinations between June 2014 and February 2018 at a regional hospital in southern Taiwan were reviewed. The data collected included health history, anthropomorphic characteristics, clinical laboratory results, biochemical parameters, and BMD. The data were used to identify the biofactors associated with BMD/T‑scores at the lumbar spine and femoral neck by multivariate linear regression analysis with the stepwise method. Results: The mean age of the patients was 58.1 years, and 71.4% were male. Factors positively correlated with BMD and the T‑score included body mass index (BMI), male gender, calcium, and creatinine. Age, alkaline phosphatase (ALP), triiodothyronine, serum thyroxine, low‑density lipoprotein cholesterol, and a history of hyperlipidemia were negatively correlated with BMD and the T‑score. Conclusion: The associated biofactors reported here were similar to and had similar relationships as the biofactors identified in previous literature reports. Not all of the sites examined for BMD were influenced by the same association factors, except for BMI, male gender, age, and ALP, implying that the bone remodeling processes that shape BMD involve a complex regulatory network and demonstrating that our extracted factors are the most useful for clinical practice.
Keywords: Bone mineral density, Factors, Health examination, Taiwan, T‑score