Hung-Chi Jesse Chen a, b, Ju-Chuan Cheng c, Ching-Hsi Hsiao a, David Hui-Kang Ma a, d
aDepartment of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
bGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
cDepartment of Ophthalmology, Cathay General Hospital-Shijhih, Taipei, Taiwan
dDepartment of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Abstract
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disorder that can have numerous ocular manifestations, which may precede or occur upon initial presentation of SLE. We report on a 72-year-old woman with peripheral corneal perforation but without any predisposing factors. SLE was diagnosed because of signs and symptoms such as arthritis, leukopenia, anemia, positive anti-dsDNA antibody, and positive antinuclear antibody (ANA). Systemic therapy with oral hydroxylchloroquine 200 mg daily was prescribed. Therapeutic penetrating keratoplasty with cryopreserved cornea was also performed to repair the perforated cornea. Six months postoperatively, the corneal lesion became scarred and her visual acuity improved from 2/200 to 20/70 without any ocular or systemic recurrence.
Keywords
Antinuclear antibody; Corneal perforation; Peripheral ulcerative keratopathy; Systemic lupus erythematosus; Therapeutic penetrating keratoplasty
