Last updateThu, 23 Jun 2022 9am

Weil's Disease Associated With Epstein-Barr Virus

Shu-Lan Hsu a, Kuo-Chih Tseng a, b, Chorng-Jang Lay a, Chen-Chi Tsai a

aDepartment of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
bDepartment of Internal Medicine, Tzu Chi University, Hualien, Taiwan

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Weil's disease caused by Leptospira species is characterized by impaired hepatic and renal function. We report a 71-year-old man with Weil's disease associated with Epstein-Barr Virus (EBV). The patient was admitted because of progressive jaundice for 1 week. EBV infection and leptospirosis were determined by serologic tests. After treatment with intravenous penicillin and minocycline, the jaundice subsided. Immunosuppression during active EBV infection has been reported previously, and therefore, this could have caused the severe symptoms after Leptospira infection in our case.


Epstein-Barr virus; Leptospirosis; Weil's disease


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