Successful Treatment of Two Cases of Invasive Aspergillus Sinusitis With Voriconazole

Chen-Hao Li ^a, Chorng-Jang Lay ^a, Yu-Huai Ho ^b, Lih-Shinn Wang ^{b, c}, Chun-Lung Wang ^a, Chen-Chi Tsai ^{a, c}

^aDivision of Infectious Disease, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
^bDivision of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
^cSchool of Medicine, Tzu Chi University, Hualien, Taiwan

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Abstract

Aspergillosis is a spectrum of diseases caused by Aspergillus spp., which is a widespread fungus that produces microscopic spores. Immunocompetent people may breathe in numerous Aspergillus every day, yet experience no symptoms. Invasive Aspergillus is relatively rare. There is limited information about the use of voriconazole for the treatment of invasive Aspergillus sinusitis. Here, we present two cases of invasive Aspergillus in elderly female patients with diabetes mellitus. Both patients fully recovered after treatment using surgical debridement and an antifungal regimen that included voriconazole.

Keywords

Aspergillosis; Sinusitis; Voriconazole