05212022Sat
Last updateWed, 09 Mar 2022 4am

Study of extended-spectrum β-lactamase-producing bacteria from urinary tract infections in Bangladesh

Shahidul Ahmed Khan, Farahnaaz Feroz, Rashed Noor

Department of Microbiology, Stamford University, Dhaka, Bangladesh

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Abstract
Objective

Production of β-lactamase by pathogens causing urinary tract infection (UTI) has been demonstrated to increase resistance to antimicrobial agents. The current study showed the prevalence of uropathogens and their antimicrobial susceptibilities, based on extended-spectrum β-lactamase (ESBL) production, in Dhaka.

Materials and Methods

The prevalence of uropathogens and their antimicrobial resistance patterns were identified in 200 isolates from patients with UTI. Double-disc diffusion and E tests were performed to determine the presence of ESBL-producing strains.

Results

The most common pathogen was Escherichia coli (57%), followed by Enterococcus spp. (10.5%), Klebsiella spp. (11%), Staphylococcus spp. (4%), Pseudomonas spp. (10%), Acinetobacter spp. (5%), and Enterobacter spp. (9%). ESBL production occurred more frequently in Klebsiella spp. (72.7%) than E. coli (53.5%), and Enterobacter spp. (66.7%).

Conclusion

The current investigation found E. coli to be the most common uropathogen. Overall, the higher frequency of antimicrobial resistance as well ESBL production by the most common pathogens found in this study may demonstrate a public health threat and therefore, the community should be made aware of this problem.

Keywords
Antimicrobial susceptibility; Extended spectrum β-lactamase; Urinary tract infection


 

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