Sex differences in the effective warfarin dosage in Han and aboriginal Taiwanese patients with the VKORC1-1639AA genotype

Chooi-Lan Liew^{a, b}, Jui-Hung Yen^b, An-Bang Liu^a, Ingrid Y. Liu^b

^a Department of Neurology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
^b Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan

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Abstract
Objective

This study aims to investigate whether single-nucleotide polymorphisms (SNPs) CYP2C9 and VKORC1 can be used to adjust effective warfarin treatment for aboriginal Taiwanese population.

Materials and Methods

This study investigates the association of SNPs CYP2C9 and VKORC1 and clinical factors [sex, age, and body mass index (BMI)] with variable responses to warfarin treatment in 42 aboriginal and 63 Han Taiwanese people.

Results

The incidence of the VKORC1-1639AA genotype and the effective warfarin dosage were similar in the populations studied. However, the required dosage of warfarin for women with VKORC1-1639AA polymorphism was significantly lower than for their male counterparts.

Conclusion

This result provides guidance for prescribing an effective warfarin dosage for aboriginal and Han Taiwanese patients with genetic polymorphisms.

Keywords
Aborigines; CYP2C9; Genetic polymorphism; VKORC1; Warfarin