05232022Mon
Last updateWed, 09 Mar 2022 4am

Antibiotic resistance patterns of uropathogens isolated from catheterized and noncatheterized patients in Dhaka, Bangladesh

Muhammad Delowar Hossaina, b, Sunjukta Ahsanc, Md. Shahidul Kabirb

a Department of Blood Transfusion Medicine, Dhaka Medical College, Dhaka, Bangladesh
b Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh
c Department of Microbiology, University of Dhaka, Dhaka, Bangladesh

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Abstract
Objectives

Catheter-associated urinary tract infection (CAUTI) is the most common device-associated nosocomial infection worldwide. Bacteria, which exist as a biofilm inside catheters, show higher antimicrobial resistance when compared to non-CAUTI pathogens. The present study was conducted to determine the antibiotic susceptibility patterns of CAUTI and non-CAUTI bacteria.

Materials and Methods

The antibiotic susceptibility patterns of 102 uropathogens from noncatheterized patients and 100 uropathogens from catheterized patients were compared using the disc diffusion method.

Results

A higher incidence of uropathogens was correlated with catheter use in male patients. Escherichia coli was the predominant isolate obtained from catheterized (81%) and noncatheterized (67%) patients. This was followed by Pseudomonas aeruginosa, with rates of 28% and 15% in non-CAUTI and CAUTI patients, respectively. Overall, the E. coli isolates from CAUTI patients showed significantly higher resistance (p < 0.05) than those from non-CAUTI patients against all antibiotics tested, except for trimethoprim/sulfamethoxazole and gentamicin. Catheter-associated P. aeruginosa isolates showed significantly higher resistance (p < 0.05) against most antibiotics tested compared to non-catheter-associated isolates.

Conclusion

Uropathogens from CAUTI patients exhibit significantly higher resistance to most antibiotics than non-CAUTI isolates. This is an important factor to take into consideration when choosing correct treatment options for patients with urinary tract infection.

Keywords
Antibiotic resistance; Catheter; Urinary tract infection


 

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