Last updateMon, 08 Aug 2022 8am

Role of micronutrients in congestive heart failure: A systematic review of randomized controlled trials

Chandini Valiyakizha Kkeveetila, Grace Thomasa, Sam Johnson Udaya Chanderb,

a KG Hospital and Postgraduate Research Institute, Coimbatore, India
b Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Coimbatore, India

Full-Text HTML Download PDF

Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation



To assess the effect of micronutrients on health outcomes in patients with heart failure.

Materials and Methods

Only randomized controlled trials testing the effectiveness of different micronutrients either singly or combined versus placebo in heart failure patients were included. We conducted a search in different databases such as Medline from PubMed, Embase and Scopus from Elsevier, and Google Scholar. The keywords used in the search were “Heart Failure” and its cognates, “Micronutrient,” “Minerals,” and names of individual micronutrients.


Out of 3288 titles and abstracts reviewed, only 11 trials comprising 529 individuals were found to be appropriate to be included in the final review. It was found that micronutrients, either single or combined, improved the health outcomes of heart failure patients by improving exercise tolerance, functional capacity, left ventricular function, flow-dependent dilation, and inflammatory milieu, thereby improving the quality of life of health failure patients. Certain micronutrients also normalized endothelial dysfunction.


Overall, this systematic review found sufficient evidence to support a large-scale trial on micronutrient supplementation in patients with heart failure.


Exercise tolerance; Functional Capacity; Heart failure; Micronutrients; Supplementation


On the Cover

Search all Issue