Pei‑Chun Lai^{a, b}, Yen‑Ta Huang^{c, d*}

^aDepartment of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation, Hualien, Taiwan, ^bSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^cDivision of Experimental Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation, Hualien, Taiwan, ^dDepartment of Pharmacology, Tzu Chi University, Hualien, Taiwan

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Hung‑Yu Cheng^a, Li‑Chuan Huang^b,c, Hsiao‑Fen Peng^d, Jon‑Son Kuo^e, Hock‑Kean Liew^d, Cheng‑Yoong Pang^b,d*

^aDepartment of Physical Medicine and Rehabilitation, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^bInstitute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ^cDepartment of Radiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^dDepartment of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^eMaster Program and PhD Program in Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan

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Chia‑Wen Lu^a†, Chung‑Jen Lee^b†, Jia‑Sian Hou^a,c, Du‑An Wu^d,e, Bang‑Gee Hsu^c,e,f*

^aDepartment of Nursing, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^bDepartment of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan, ^cInstitute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ^dDepartment of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^eSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^fDepartment of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan

†Both authors contributed equally to this work.

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Kai‑Chun Changa, Ling‑Yi Wangb, Jen‑Hung Wangb, Cheng‑Kuang Shawa, Ming‑Jay Hwanga, Chih‑Hao Wua, Huai‑Kuan Huanga*

^aDepartment of Dentistry, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^bDepartment of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan

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Chien‑Yuan Huang^a,†, Kuang‑Ting Yeh^a,b,†, Tzai‑Chiu Yu^a,b, Ru‑Ping Lee^c, Ing‑Ho Chen^a,b, Cheng‑Huan Peng^a, Kuan‑Lin Liu^a, Jen‑Hung Wangd, Wen‑Tien Wu^a,b*

^aDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^bSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^cInstitute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ^dDepartment of Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

†Both authors contributed equally to this work.

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Yi‑Chen Sun^a,b*, Jason P. Kam^b, Tueng T. Shen^b

^aDepartment of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan, ^bDepartment of Ophthalmology, University of Washington, Seattle, WA, USA

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Leay‑Kiaw Er^a, Ming‑Sheng Teng^b, Semon Wu^b,c, Lung‑An Hsu^d, I‑Shiang Tzeng^b, Ching‑Feng Cheng^e,f, Hsin‑I Chang^g, Hsin‑Hua Chou^f,g, Yu‑Lin Ko^b,f,g*

^aDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan, ^bDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan, ^cDepartment of Life Science, Chinese Culture University, Taipei, Taiwan, ^dFirst Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan, ^eDepartment of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^fSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^gDivision of Cardiology, Department of Internal Medicine and Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan

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Sheng‑Po Kaoa, b, Tsung‑Ying Chena, b, Mei‑Lin Hsiehc*

^aDepartment of Medical Education, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^bSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^cDepartment of Nursing, Tzu Chi University, Hualien Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Vipul D. Yagnik^*

Department of Surgical Gastroenterology, Ronak Endo‑Laparoscopy and General Surgical Hospital, Patan, Gujarat, India

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Wen‑Kuei Fang^a, Yeong‑Chin Jou^a*, Yuan‑Chang Dai^b, Pi‑Chan Ko^a, Ya‑Fang Huang^a

^aDepartment of Surgery, Ditmanson Medical Foundation Chia‑Yi Christian Hospital, Chiayi, Taiwan, ^bDepartment of Pathology, Ditmanson Medical Foundation Chia‑Yi Christian Hospital, Chiayi, Taiwan

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Jia‑Hui Chen^a,b*

^aDivision of General Surgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan, ^bGraduate Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Yen‑Kuang Lin^a,b, Mu‑Tsu Hsu^b, Ming‑Chen Hsieh^a,c,d*

^aDepartment of Internal Medical, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^bDepartment of Human Development and Psychology, Tzu Chi University, Hualien, Taiwan, ^cDepartment of Medical Education, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ^dSchool of Medicine, Tzu Chi University, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Reddy Ravikanth^a*, Anush Nagotu^b

^aDepartment of Radiology, St. John’s Medical College, Bengaluru, Karnataka, India, ^bDepartment of General Surgery, St. John’s Medical College, Bengaluru, Karnataka, India

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation