Jui-Hung Yen^a†, Chun-Chun Chang^b,c†, Tien-Yuan Wu^d, Chin-Hao Yang^e, Hao-Jen Hsu^f*, Je-Wen Liou^c,e,f*

Yun Yen^a, Tang‑Yuan Chu^b,c, Ruo‑Chia Tseng^d*

^aCenter for Cancer Translational Research, Tzu Chi University, Hualien, Taiwan, ^bCenter for Prevention and Therapy of Gynecological Cancers, Department of Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^cDepartment of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^dDepartment of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan

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Kuang‑Ting Yeh^a,b,c,d, Wen‑Tien Wu^a,b,d, Chia‑Ming Chang^b, Tzai‑Chiu Yu^a,b, Ing‑Ho Chen^b, Chen‑Chie Wang^a,e*

^aSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^bDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^cGraduate Institute of Clinical Pharmacy, Tzu Chi University, Hualien, Taiwan, ^dInstitute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ^eDepartment of Orthopedic Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Du‑An Wu^a,b, Bang‑Gee Hsu^b,c, Yu‑Li Lin^b,c*

^aDivision of Metabolism and Endocrinology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^bSchool of Medicine, Tzu Chi University, Hualien, Taiwan, ^cDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Ming-Chun Chen^a,b, Chiu-Huang Kuo^c,d, Yu-Li Lin^b,d, Bang-Gee Hsu^b,d*

Ting‑Hsu Chen^a†, Zi‑Han Shen^b†, May‑Jywan Tsai^c, Ching‑Feng Weng^d*, Max K. Leong^e*

Huan‑Ting Shen^a, Peng‑Ju Chien^b, Gwo‑Tarng Sheu^c, Bing-Yen Wang^d,e*, Wen-Wei Chang^b,f*

^aDepartment of Pulmonary Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, ^bDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan, ^cInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ^dDivision of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan, ^eDepartment of Post‑Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan, ^fDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

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Jing‑Wun Lu^a, Sheng‑Hsiang M^ab,c,d, Wei‑Fan Ou^e, Hsin‑Hua Chen^c,f,g,h, Tai‑Li Chen^b,c*, Chung‑Chao Liang^a,i*

^aDepartment of Physical Medicine and Rehabilitation, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^bDepartment of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, ^cFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ^dDepartment of Public Health, Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan, ^eDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ^fBig Data Center, Chung Hsing University, Taichung, Taiwan, ^gDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ^hDivision of General Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ⁱSchool of Medicine, Tzu Chi University, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Chen‑Lun Chu^a, Tai‑Yin Wu^b,c,d,e, Sheng‑Mou Hou^a, Kao‑Shang Shih^a,f, Yo‑Lun Chu^a,f,g, Cheng‑Kuang Chen^a,g, Li‑Wei Hung^a,f, Hao‑Wei Hsu^a,g, Chen‑Kun Liaw^a*

^aDepartment of Orthopedics, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ^bDepartment of Family Medicine, Zhongxing Branch, Taipei City Hospital, Taipei, Taiwan, ^cInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan, ^dDepartment of Social and Public Affairs, University of Taipei, Taipei, Taiwan, ^eDepartment of Health and Welfare, University of Taipei, Taipei, Taiwan, ^fSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan, ^gDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Yi-Ting Chen^a,b*, Ya-Ju Wu^a, Li-Liang Chuang^a, Hui-Sheng Wang^c, Yuan-Chieh Chang^c

Phyo‑Wai Thu^a, Yu‑Ping Yu^a, Jen‑Hung Wang^b, Chooi‑Lan Liew^a*

^aStroke Center, Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^bDepartment of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Raymond Y. Lo^a,b,c*, Yuncin Luo^a,d, Shu‑Cin Chen^b, Jen‑Hung Wang^e, Chen‑Yu Ko^f, Ying‑Jie Chen^f, Yu‑Chin Su^f, Tong‑Young Lee^f, Jonas C. Wang^g, Shinn‑Zong Lin^h

^aDepartment of Neurology, Taitung St. Mary’s Hospital, Taitung, Taiwan, ^bDepartment of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^cDepartment of Biochemistry and Molecular Medicine, National Dong Hwa University, Hualien, Taiwan, ^dCollege of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ^eDepartment of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ^fStemCyte Taiwan Co., Ltd., Taipei, Taiwan, ^gStemCyte Inc., CA, USA, hDepartment of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation

Chuan‑Hsin Chang^a,b, Chih‑Cheng Chien^c, Yue‑Cune Chang^d*

^aDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan, ^bResearch Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ^cInstitute of Ecology and Evolutionary Biology, National Taiwan University, Taipei, Taiwan, ^dDepartment of Mathematics, Tamkang University, New Taipei, Taiwan

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Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation