Last updateWed, 09 Mar 2022 4am

Reversible Leukoencephalopathy Due to Cobalamin Deficiency After Subtotal Thyroidectomy for Graves' Thyrotoxicosis

Chih-Yuan Lin, Yue-Loong Hsin, Wen-Long Tsao

Department of Neurology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan

Download PDF


We report a woman aged 37 years who showed rapid deterioration of psychomotor functions 6 months after a subtotal thyroidectomy for Graves' thyrotoxicosis. In addition to cobalamin deficiency, we observed pathologic changes in the brain tissue in accordance with a white matter disorder on brain imaging. The neurologic deficits and leukoencephalopathic changes in brain imaging responded to cobalamin replacement and returned to normal 6 months after treatment. The relationship between thyroid dysfunction and cobalamin levels in maintaining white matter is briefly reviewed.


Cobalamin; Leukoencephalopathy; Thyroid; White matter


On the Cover

Search all Issue