Intranasal endoscopic surgery combined with adjuvant radiation therapy for olfactory neuroblastoma

Zong-Sin Wu^a, Hsu-Chueh Ho^{a, b}, Jeh-En Tzeng^{b, c}, Shih-Hsuan Hsiao^{a, b}

^a Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
^b School of Medicine, Tzu Chi University, Hualien, Taiwan
^c Department of Pathology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan

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Abstract
Olfactory neuroblastoma, also known as esthesioneuroblastoma, is a rare malignant head and neck tumor. Olfactory neuroblastoma accounts for approximately 3–5% of all malignant nasal tumors. We present a case of olfactory neuroblastoma in a 61-year-old man who underwent endoscopic surgery followed by postoperative irradiation. Right neck metastasis was diagnosed about 6 months after endoscopic surgery. Supraomohyoid dissection of the right side of the neck was performed, but right parotid metastasis was identified about 3 months later. Boost radiotherapy was applied to the right metastatic parotid. There was no evidence of recurrence on head and neck magnetic resonance imaging and endoscopic examination during the 2-year follow-up.

Keywords
Endoscopic surgery; Metastasis; Olfactory neuroblastoma; Positron emission tomography; Radiation therapy