CREB-regulated transcription coactivator 3 (CRTC3) polymorphism associated with type 2 diabetes and hyperlipidemia in the Taiwanese population

Kuei-Fang Lee^{a, b}, †, Cheng-Chia Lin^c, †, Tsung-Cheng Hsieh^a, Chun-Te Wu^c, Lawrence Shih-Hsin Wu^a,

^a Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
^b Laboratory for Cytogenetics, Center for Genetic Counseling, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
^c Department of Urological Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan

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Abstract
Objective

Type 2 diabetes mellitus (T2D) is a pathologically and genetically heterogeneous disease influenced by genetic and environmental factors. This study aims to investigate the association between T2D and polymorphism(s) in CREB-regulated transcription coactivator 3 (CRTC3) in Asian Taiwan.

Materials and methods

In this study, 417 participants with T2D and 197 without T2D were recruited. Anthropometrics, the metabolic profile, blood pressure, fasting plasma glucose, glycosylated hemoglobin (HbA1c), serum triglycerides, serum total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), and C-peptide were analyzed. TaqMan genotyping was used to identify individual genotypes, and the association of CRTC3 polymorphism with clinical and biochemical parameters was assessed.

Results

Single nucleotide polymorphism (SNP) rs8033595 showed an association with diabetes (p = 0.031) and hyperlipidemia (p = 0.002). Odds ratio analysis showed that A carriers (AA or AG) had a protective effect against developing T2D and hyperlipidemia. Moreover, individuals with the GG genotype had higher frequencies of developing T2D and hyperlipidemia comorbidity.

Conclusion

In this study, conducted for the first time in Asian Taiwan, rs8033595 of the CRTC3 gene was associated with T2D and hyperlipidemia in our study population.

Keywords
CRTC3; Hyperlipidemia; SNP; Type 2 diabetes