Chih-Hsien Wanga, †, Jen-Pi Tsaib, c, †, Yu-Hsien Laia, Yu-Li Lina, Chiu-Huang Kuoa, Bang-Gee Hsua, c
a Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
b Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
c School of Medicine, Tzu Chi University, Hualien, Taiwan
Open Access funded by Buddhist Compassion Relief Tzu Chi Foundation
Abstract
Objective
Chronic kidney disease is associated with decreased bone mineral density (BMD). In this study, the relationship between BMD and the fasting serum concentration of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) was evaluated in peritoneal dialysis (PD) patients.
Material and Methods
Fasting blood samples were obtained from 52 PD patients. BMD was measured by dual energy X-ray absorptiometry of the lumbar vertebrae (L2–L4). The serum NT-pro-BNP level was measured by an electrochemiluminescence immunoassay.
Results
Ten patients (19.2%) had osteoporosis, 23 patients (44.2%) had osteopenia, and 19 patients had normal BMD. Increased serum NT-pro-BNP (p < 0.001), advanced age (p = 0.012), decreased body mass index (p = 0.006), body height (p = 0.018), and body weight (p = 0.004) were associated with lower lumbar T-scores, but sex, menopausal status, PD modality, diabetes mellitus, and hypertension were not. Multivariate forward stepwise linear regression analysis with adjustment for age, body height, body weight, body mass index, and log-NT-pro-BNP indicated that a high serum level of log-NT-pro-BNP (R2 change = 0.346; p < 0.001) and low body weight (R2 change = 0.208; p < 0.001) were significantly and independently associated with poor lumbar BMD.
Conclusion
A high serum level of NT-pro-BNP and low body weight were associated with poor BMD in PD patients.
Keywords
Bone mineral density; N-terminal pro-B-type natriuretic peptide; Peritoneal dialysis
